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Renato Spaziante Selected Research

Chemokine CXCL12

8/2008Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas.
1/2007CXCR4 and SDF1 expression in human meningiomas: a proliferative role in tumoral meningothelial cells in vitro.
12/2006CXC receptor and chemokine expression in human meningioma: SDF1/CXCR4 signaling activates ERK1/2 and stimulates meningioma cell proliferation.
2/2006Chemokine stromal cell-derived factor 1alpha induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals.
4/2003Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt.
11/2002Expression of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1 in human brain tumors and their involvement in glial proliferation in vitro.

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Renato Spaziante Research Topics

Disease

14Neoplasms (Cancer)
11/2012 - 04/2003
6Meningioma (Meningiomas)
11/2012 - 01/2004
6Glioma (Gliomas)
01/2012 - 07/2004
5Glioblastoma (Glioblastoma Multiforme)
03/2009 - 04/2003
5Pituitary Neoplasms (Pituitary Adenoma)
08/2008 - 10/2002
4Adenoma (Adenomas)
03/2016 - 10/2002
2Growth Hormone-Secreting Pituitary Adenoma
08/2008 - 07/2003
1Hypopituitarism (Sheehan's Syndrome)
03/2016
1Wounds and Injuries (Trauma)
08/2011
1Leukemia
08/2011
1Tics (Tic)
03/2009
1Neoplasm Metastasis (Metastasis)
01/2008
1Acromegaly
05/2007
1Meningeal Neoplasms
12/2006
1Craniopharyngioma (Craniopharyngiomas)
04/2006
1Infections
11/2002
1Cicatrix (Scar)
11/2002
1Brain Neoplasms (Brain Tumor)
11/2002

Drug/Important Bio-Agent (IBA)

7Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
03/2016 - 07/2003
7Messenger RNA (mRNA)IBA
08/2008 - 04/2003
6LigandsIBA
05/2011 - 11/2002
6Chemokine CXCL12IBA
08/2008 - 11/2002
5Growth Hormone (Somatotropin)IBA
03/2016 - 10/2002
5DNA (Deoxyribonucleic Acid)IBA
08/2008 - 07/2003
5ChemokinesIBA
08/2008 - 04/2003
4Proteins (Proteins, Gene)FDA Link
03/2009 - 01/2004
4CXCR4 Receptors (CXCR4 Receptor)IBA
08/2008 - 11/2002
4Somatostatin Receptors (Somatostatin Receptor)IBA
06/2008 - 07/2003
4ThymidineIBA
01/2007 - 07/2003
3Chemokine ReceptorsIBA
05/2011 - 11/2002
3Octreotide (Sandostatin)FDA LinkGeneric
06/2008 - 05/2007
3RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
01/2007 - 10/2002
2Insulin-Like Growth Factor I (IGF-1)IBA
03/2016 - 07/2003
2Biomarkers (Surrogate Marker)IBA
11/2012 - 01/2012
2Biological ProductsIBA
01/2012 - 04/2007
2Phosphoric Monoester Hydrolases (Phosphatases)IBA
03/2009 - 07/2003
2Phosphotransferases (Kinase)IBA
03/2009 - 04/2003
2Dopamine (Intropin)FDA LinkGeneric
06/2008 - 05/2007
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2007 - 12/2006
22- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- oneIBA
01/2007 - 12/2006
2CXC ChemokinesIBA
10/2006 - 11/2002
2Bovine Serum AlbuminIBA
07/2003 - 04/2003
1Insulin (Novolin)FDA Link
03/2016
1NectinsIBA
03/2009
1TensinsIBA
03/2009
1Erlotinib Hydrochloride (CP 358,774)FDA Link
03/2009
1ErbB Receptors (EGF Receptor)IBA
03/2009
1Gefitinib (Iressa)FDA Link
03/2009
1NestinIBA
03/2009
1plerixaforFDA Link
08/2008
1TBR-760IBA
06/2008
1CabergolineFDA LinkGeneric
06/2008
1Proliferating Cell Nuclear Antigen (PCNA)IBA
04/2007
1Cyclin D1IBA
04/2007
1Mucin-1 (CA 15-3 Antigen)IBA
01/2007
1Mitogen-Activated Protein Kinase 3IBA
01/2007
1ParaffinIBA
01/2007
1Interferon-gamma (Interferon, gamma)IBA
12/2006
1Interleukin-8 (Interleukin 8)IBA
12/2006
1CXCR ReceptorsIBA
10/2006
1phosphotyrosine phosphatase etaIBA
12/2004
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
12/2004
11-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (DEP)IBA
07/2004
1Protein Tyrosine PhosphatasesIBA
07/2004
1CarcinogensIBA
01/2004
1Tetradecanoylphorbol AcetateIBA
01/2004
1Vanadates (Orthovanadate)IBA
07/2003
1Tyrosine (L-Tyrosine)FDA Link
07/2003
1Phorbol EstersIBA
07/2003
1Hormones (Hormone)IBA
07/2003
1ColforsinIBA
07/2003
1Adenylyl Cyclases (Adenylyl Cyclase)IBA
07/2003
1somatostatin receptor type 1IBA
07/2003
1lanreotide (Somatuline)FDA Link
07/2003
1Calcium Channels (Calcium Channel)IBA
07/2003
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
04/2003
1LipopolysaccharidesIBA
04/2003
1baysilon (polydimethylsiloxane)IBA
11/2002
1LeptinIBA
10/2002
1Leptin ReceptorsIBA
10/2002
1Protein Isoforms (Isoforms)IBA
10/2002

Therapy/Procedure

2Radiotherapy
08/2011 - 04/2006
2Therapeutics
05/2007 - 01/2004
1Cranial Irradiation
08/2011
1Craniotomy
08/2007